Relative Contribution of Adipose Triglyceride Lipase and Hormone- Sensitive Lipase to Tnf-α-induced Lipolysis in Adipocytes
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چکیده
RELATIVE CONTRIBUTION OF ADIPOSE TRIGLYCERIDE LIPASE AND HORMONESENSITIVE LIPASE TO TNF-α-INDUCED LIPOLYSIS IN ADIPOCYTES Xingyuan Yang, Xiaodong Zhang, Bradlee L. Heckmann , Xin Lu, and Jun Liu From Department of Biochemistry and Molecular Biology, Mayo/ASU Center for Metabolic and Vascular Biology, Mayo Clinic in Arizona, Scottsdale, Arizona 85259, USA. Markey Cancer Center, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA. Running title: Roles of ATGL and HSL in TNF-α-Induced Lipolysis
منابع مشابه
Contribution of adipose triglyceride lipase and hormone-sensitive lipase to lipolysis in hMADS adipocytes.
Lipolysis is the catabolic pathway by which triglycerides are hydrolyzed into fatty acids. Adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) have the capacity to hydrolyze in vitro the first ester bond of triglycerides, but their respective contributions to whole cell lipolysis in human adipocytes is unclear. Here, we have investigated the roles of HSL, ATGL, and its coactiv...
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Hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL) regulate adipocyte lipolysis in rodents. The purpose of this study was to compare the roles of these lipases for lipolysis in human adipocytes. Subcutaneous adipose tissue was investigated. HSL and ATGL protein expression were related to lipolysis in isolated mature fat cells. ATGL or HSL were knocked down by RNA interference...
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تاریخ انتشار 2011